Impaired Mitochondrial Function due to Familial Alzheimers Disease-Causing Presenilins Mutants via Calcium Disruptions
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چکیده
منابع مشابه
Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer’s Disease-Causing Mutants in Presenilins
Familial Alzheimer's disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+) release channels resulting in enhanced IP3R channel gating in an amyloid beta (Aβ) production-independent manner. This gain-of-function enhancement of IP3R activity is considered to be the main reason behind the upregulation of intracellular Ca(2+) signaling...
متن کاملPresenilins, Alzheimer's Disease, and Capacitative Calcium Entry
the endoplasmic reticulum to the plasma membrane channels. There is considerable evidence indicating that activation of plasma membrane capacitative calcium Currently about 20 million people suffer from the debili-entry channels depends on interaction with IP 3 receptors tating age-related dementia known as Alzheimer's dis-in closely juxtaposed endoplasmic reticulum (Kiselyov ease (Haass and De...
متن کاملPresenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder. Mutations in presenilins 1 and 2 (PS1 and PS2) account for approximately 40% of familial AD (FAD) cases. FAD mutations and genetic deletions of presenilins have been associated with calcium (Ca(2+)) signaling abnormalities. We demonstrate that wild-type presenilins, but not PS1-M146V and PS2-N141I FAD mutants...
متن کاملPresenilins FormERCa Leak Channels, a Function Disrupted by Familial Alzheimer’s Disease-Linked Mutations
Huiping Tu, Omar Nelson, Arseny Bezprozvanny, Zhengnan Wang, Sheu-Fen Lee, Yi-Heng Hao, Lutgarde Serneels, Bart De Strooper, Gang Yu, and Ilya Bezprozvanny* Department of Physiology Center for Basic Neuroscience UT Southwestern Medical Center at Dallas, Dallas, TX, 75390, USA Neuronal Cell Biology and Gene Transfer, Center for Human Genetics, Flanders Interuniversity Institute for Biotechnology...
متن کاملPresenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.
Presenilin (PS) plays a central role in the pathogenesis of Alzheimer's disease, and loss of PS causes progressive memory impairment and age-related neurodegeneration in the mouse cerebral cortex. In hippocampal neurons, PS is essential for neurotransmitter release, NMDA receptor-mediated responses, and long-term potentiation. PS is also involved in the regulation of calcium homeostasis, althou...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.11.1670